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In obstructive rest apnea (OSA), doses around 250 mg/working day have been well-tolerated but there's no dependable proof of extra reward past the 150 mg/working day.No specific dose adjustment recommended when tofacitinib coadministered with powerful CYP2C19 inhibitors; decrease tofacitinib dose if coadministered with each average CYP3A4 and poten